Lewis Base Catalysed Synthesis and Spectral Analysis of Aromatic Hetero Cyclic Compounds

PPh3 have been utilized as a novel and efficient chemoselective C-C bond formation, without alter active chlorine atom. This catalyst
using for synthesis of novel Indolyl Quinolines by Knoevenagel condensation. The reaction of 2-chloroquinoline-3-aldehyde (2) with
the active methylene compound, i.e. 3-cyanoacetylindoles (3), in ethanol at room temperature for 20 min to afford (E)-3-(2-
chloroquinolin-4-yl-)-2-(1H-indole-3-carbonyl)acrylonitrile (4). Subsequently, these were reacted with benzenesulfonyl chloride in
CHCl3 the presence of tetrabutylammoniumbromide (TBAB) as an efficient phase transfer catalyst (PTC) to afford the corresponding
derivatives i.e.(E)-3-(2-chloroquinolin-4-yl-)-2-(1-benzenesulfonyl-1H-indole-3-carbonyl)acrylonitrile (5). Compound 2 was prepared
from acetanilide (1) using a well-known procedure by Vilsmeier-Hack reaction.